Bruising runner Manu Tuilagi makes his return to the England line-up after being named at outside centre for the clash against Argentina on Sunday.
Owen Farrell starts alongside Tuilagi in the midfield and will captain the side, while vice-captain Jack Nowell starts on the right wing with Joe Cokanasiga and Freddie Steward in the back three.
Star fly-half Marcus Smith links up with Ben Youngs in the half-back pairing.
Elsewhere, Alex Coles makes his Test debut in the second-row in a paring with Jonny Hill, while vice-captain Ellis Genge, Luke Cowan-Dickie and Kyle Sinckler are the starting front-row.
Changed back-row
Maro Itoje finds himself on the flank alongside Tom Curry and number eight Billy Vunipola in the back-row.
David Ribbans may also make his debut if used from the bench, while Mako Vunipola, Joe Heyes, Sam Simmonds and Jack Willis make up the remaining forward options in a 6/2 split.
Scrum-half Jack van Poortvliet and Henry Slade are the backline options for head coach Eddie Jones.
Jones is looking forward to a tough Test against Argentina but is happy with the team’s preparation during the week.
“It’s been a really good week of preparation and I’ve been very pleased with the squad’s attitude,” he said.
“They’ve shown real work ethic and a determination to improve and our leaders, Owen, Ellis and Jack have really lifted the team.
Great game at HQ
“We’re looking forward to a great game of rugby at a full Twickenham Stadium against a very good Argentina side. It’s been a tough time for rugby lately and we hope that these autumn games show just what a special game it is.”
England: 15 Freddie Steward, 14 Jack Nowell, 13 Manu Tuilagi, 12 Owen Farrell (c), 11 Joe Cokanasiga, 10 Marcus Smith, 9 Ben Youngs, 8 Billy Vunipola, 7 Tom Curry, 6 Maro Itoje, 5 Jonny Hill, 4 Alex Coles, 3 Kyle Sinckler, 2 Luke Cowan-Dickie, 1 Ellis Genge
Replacements: 16 Jack Singleton, 17 Mako Vunipola, 18 Joe Heyes, 19 David Ribbans, 20 Sam Simmonds, 21 Jack Willis, 22 Jack van Poortvliet, 23 Henry Slade
Date: Sunday, November 6
Venue: Twickenham
Kick-off: 14:15 GMT
Referee: Andrew Brace (IRFU)
Assistant Referees: Frank Murphy (IRFU), Pierre Brousset (FFR)
TMO: Marius Jonker (SARU)
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