{"id":11452,"date":"2024-11-27T12:35:42","date_gmt":"2024-11-27T12:35:42","guid":{"rendered":"https:\/\/googmn.com\/?p=11452"},"modified":"2024-11-27T12:35:42","modified_gmt":"2024-11-27T12:35:42","slug":"depsipeptide-companeramides-from-a-panamanian-marine-cyanobacter","status":"publish","type":"post","link":"https:\/\/googmn.com\/?p=11452","title":{"rendered":"Depsipeptide Companeramides from a Panamanian Marine Cyanobacter"},"content":{"rendered":"<p><strong>Depsipeptide Companeramides from a Panamanian Marine Cyanobacterium Associated with the Coibamide Producer<\/strong><\/p>\n<p>Oliver B. Vining,\u00a0Rebecca A. Medina,\u00a0Edward A. Mitchell,\u00a0Patrick Videau,\u00a0Dong Li,\u00a0Jeffrey D. Serrill,\u00a0Jane X. Kelly,\u00a0William H. Gerwick,Philip J. Proteau,\u00a0Jane E. Ishmael, and\u00a0Kerry L. McPhail, J. Nat. Prod., Article ASAP, Publication Date (Web): January 6, 2015 \u00a0DOI:\u00a010.1021\/np5007907<\/p>\n<p>Two new cyclic depsipeptides, companeramides A (1) and B (2), have been isolated from the phylogenetically characterized cyanobacterial collection that yielded the previously reported cancer cell toxin coibamide A (collected from Coiba Island, Panama). The planar structures of the companeramides, which contain 3-amino-2-methyl-7-octynoic acid (Amoya), hydroxy isovaleric acid (Hiva), and eight \u00ce\u00b1-amino acid units, were established by NMR spectroscopy and mass spectrometry. The absolute configuration of each companeramide was assigned using a combination of Marfey\u00e2\u20ac\u2122s methodology and chiral-phase HPLC analysis of complete and partial hydrolysis products compared to commercial and synthesized standards. Companeramides A (1) and B (2) showed high nanomolar in vitro antiplasmodial activity but were not overtly cytotoxic to four human cancer cell lines at the doses tested.<\/p>\n<div style=\"padding: 10px 0\">\n<p>Keyword: <a href=\"https:\/\/www.linkpeptide.com\/research-peptides\/\">Research Peptides USA Supplier<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Depsipeptide Companeramides from a Panamanian Marine Cyanobacterium Associated with the Coibamide Producer Oliver B. Vining,\u00a0Rebecca A. Medina,\u00a0Edward A. Mitchell,\u00a0Patrick Videau,\u00a0Dong Li,\u00a0Jeffrey D. Serrill,\u00a0Jane X. Kelly,\u00a0William H. Gerwick,Philip J. Proteau,\u00a0Jane E. Ishmael, and\u00a0Kerry L. McPhail, J. Nat. Prod., Article ASAP, Publication Date (Web): January 6, 2015 \u00a0DOI:\u00a010.1021\/np5007907 Two new cyclic depsipeptides, companeramides A (1) and B&#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-11452","post","type-post","status-publish","format-standard","hentry","category-read"],"_links":{"self":[{"href":"https:\/\/googmn.com\/index.php?rest_route=\/wp\/v2\/posts\/11452","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/googmn.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/googmn.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/googmn.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11452"}],"version-history":[{"count":0,"href":"https:\/\/googmn.com\/index.php?rest_route=\/wp\/v2\/posts\/11452\/revisions"}],"wp:attachment":[{"href":"https:\/\/googmn.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11452"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/googmn.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11452"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/googmn.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}